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Article

Bayesian Bidirectional Mendelian Randomization Under Correlated and Uncorrelated Pleiotropy Using GWAS Summary Statistics.

Statistics in medicine - 1 Jul 2026

Chen Siyi

Abstract excerpt

Mendelian randomization (MR) uses genetic variants as instruments to study causal relationships between traits. Standard unidirectional MR approaches are vulnerable to pleiotropy and typically assume that pleiotropic effects are independent of instrument strength, assumptions that may fail when causation operates in both directions. We propose BayBiMR, a Bayesian bidirectional MR framework that jointly estimates...

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Identifiers

PMID: 42433205
DOI: 10.1002/sim.70667
PMCID: PMC13355236

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