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Investigation of polygenic risk scores and subphenotypes in social anxiety disorder.

Translational psychiatry - 11 Jul 2026

Sindermann Lisa, Röhrig Angelina, David Friederike S, Schmidt Börge, Domschke Katharina, Nieratschker Verena, Dannlowski Udo, Leehr Elisabeth J, Leibing Eric, Nöthen Markus M, Geiser Franziska, Schumacher Johannes, Maj Carlo, Conrad Rupert, Forstner Andreas J

Abstract excerpt

Social anxiety disorder (SAD) is a common anxiety disorder (ANX) with moderate heritability that often co-occurs with other mental disorders. Until now, sample sizes in genetic analyses of SAD have been limited, so that the genetic basis of SAD and its subphenotypes is still largely unknown. In a large cohort comprising n = 1,194 SAD patients derived from five German cohorts and n = 3,409 controls from the Heinz...

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Identifiers

PMID: 42431851
DOI: 10.1038/s41398-026-04155-7
PMCID: PMC13354785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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