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Article

Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study.

Cardiovascular diabetology - 18 Apr 2025

Liu Dong, Dou Chun, Ye Chaojie, Kong Lijie, Zhu Zheng, Chen Mingling, Zheng Jie, Xu Min, Xu Yu, Li Mian, Zhao Zhiyun, Lu Jieli, Chen Yuhong, Ning Guang, Wang Weiqing, Bi Yufang, Wang Tiange

Abstract excerpt

BACKGROUND: Delineating the causal chain effects of reproductive traits and fat- and muscle-related traits on cardiovascular disease (CVD) is essential for optimizing precision prevention and control of cardiovascular health in women. METHODS: In this study, we applied the two-sample Mendelian randomization (MR) analyses and two-step MR framework to investigate the causal chain effects and the mediating effect...

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Identifiers

PMID: 40251560
DOI: 10.1186/s12933-025-02681-0
PMCID: PMC12008983

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