Article
Genetic predisposition to bone mineral density and their health conditions in East Asians.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 5 Aug 2024
Lin Ying-Ju, Liang Wen-Miin, Chiou Jian-Shiun, Chou Chen-Hsing, Liu Ting-Yuan, Yang Jai-Sing, Li Te-Mao, Fong Yi-Chin, Chou I-Ching, Lin Ting-Hsu, Liao Chiu-Chu, Huang Shao-Mei, Tsai Fuu-Jen
Abstract excerpt
Osteoporosis, a condition defined by low BMD (typically < -2.5 SD), causes a higher fracture risk and leads to significant economic, social, and clinical impacts. Genome-wide studies mainly in Caucasians have found many genetic links to osteoporosis, fractures, and BMD, with limited research in East Asians (EAS). We investigated the genetic aspects of BMD in 86 716 individuals from the Taiwan Biobank and their...
Topics
- Aged
- Female
- Humans
- Male
- Middle Aged
- Body Mass Index
- Bone Density
- Diabetes Mellitus, Type 2
- East Asian People
- Genome-Wide Association Study
- Linkage Disequilibrium
- Mendelian Randomization Analysis