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Sarcomatous Transformation of an IDH-Mutant Astrocytoma With an Oligosarcoma-Like Methylation Profile.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Aug 2026

Liu Jing, Wen Caiyan, Lin Fan, Liu Xia

Abstract excerpt

We report a rare case of oligosarcoma, IDH-mutant, arising from a recurrent astrocytoma in a male in his 50s. The patient was originally diagnosed with IDH-mutant astrocytoma, CNS WHO grade 2, lacking 1p/19q co-deletion. At recurrence, the tumor exhibited a pure spindle cell sarcoma morphology, with retained IDH1 R132H, ATRX, and TP53 mutations, homozygous CDKN2A/B deletion, and a methylation profile classifying...

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Astrocytoma
Brain Neoplasms
Cell Transformation, Neoplastic
DNA Methylation
Isocitrate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

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Identifiers

PMID: 42414232
DOI: 10.1111/neup.70069

Genes

ATRX
CDKN2A
IDH1
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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