Article
Oligosarcomas, IDH-mutant are distinct and aggressive.
Acta neuropathologica - 1 Feb 2022
Suwala Abigail K, Felix Marius, Friedel Dennis, Stichel Damian, Schrimpf Daniel, Hinz Felix, Hewer Ekkehard, Schweizer Leonille, Dohmen Hildegard, Pohl Ute, Staszewski Ori, Korshunov Andrey, Stein Marco, Wongsurawat Thidathip, Cheunsuacchon Pornsuk, Sathornsumetee Sith, Koelsche Christian, Turner Clinton, Le Rhun Emilie, Mühlebner Angelika, Schucht Philippe, Özduman Koray, Ono Takahiro, Shimizu Hiroaki, Prinz Marco, Acker Till, Herold-Mende Christel, Kessler Tobias, Wick Wolfgang, Capper David, Wesseling Pieter, Sahm Felix, von Deimling Andreas, Hartmann Christian, Reuss David E
Abstract excerpt
Oligodendrogliomas are defined at the molecular level by the presence of an IDH mutation and codeletion of chromosomal arms 1p and 19q. In the past, case reports and small studies described gliomas with sarcomatous features arising from oligodendrogliomas, so called oligosarcomas. Here, we report a series of 24 IDH-mutant oligosarcomas from 23 patients forming a distinct methylation class. The tumors were...
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