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Article

In vivo and in vitro antitumor effects of a staphylococcal enterotoxin A mutant (SEA-H61D).

Cancer investigation - 1 Oct 2010

Wang Hai-Rong, Jiang Hua, Hao Huai-Jie, Zheng Yu-Ling, Jie Ke-Ge, Gu Jun, Jiang Yong-Qiang

Abstract excerpt

In this study, we evaluated SEA-H61D, a staphylococcal enterotoxin A mutant without emetic activity, as an antitumor agent in vitro and in vivo. It showed that SEA-H61D could significantly inhibit the growth of many cancer cell lines in vitro at very low concentrations by activating human peripheral blood mononuclear cells (PBMCs). CD4+ and CD8+ T lymphocytes could be activated at a dose between 125 and 500...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20504220
DOI: 10.3109/07357900903286982

Genes

SEA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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