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Article

Prime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses.

Life sciences - 1 Oct 2026

Kim Min Woo, Park Jeong Hwan, Lee Myeonghee, Lee Seul-Gi, Oh Jeong-Seop, Park Shinhye, Jeong Youngin, Kim Yoonseo, Shin Hyewon, Kim Jin, Kim C-Yoon, Chung Hyung Min

Abstract excerpt

Short QT syndrome (SQTS) is a genetically inherited autosomal dominant cardiac channelopathy associated with paroxysmal atrial and ventricular fibrillation, syncope, and sudden cardiac arrest. Although SQTS is a well-known arrhythmogenic disorder, no optimal therapies currently exist due to its rarity and the challenges associated with diagnosis. Rodent models and patient-derived induced pluripotent stem cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42413163
DOI: 10.1016/j.lfs.2026.124573

Genes

KCNJ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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