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Article

Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

Basic research in cardiology - 1 Mar 2016

Malan Daniela, Zhang Miao, Stallmeyer Birgit, Müller Jovanca, Fleischmann Bernd K, Schulze-Bahr Eric, Sasse Philipp, Greber Boris

Abstract excerpt

Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mutations in the SCN5A cardiac sodium channel gene which mediates the fast Nav1.5 current during...

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Source

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Identifiers

PMID: 26803770
DOI: 10.1007/s00395-016-0530-0
PMCID: PMC4724360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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