Article
SLC4A3-related short QT syndrome assessed in human induced pluripotent stem cell-derived cardiomyocytes: mechanisms of ventricular arrhythmia and sudden cardiac death.
European heart journal - 16 Jun 2026
Meng Zenghui, Kovacs Boldizsar, Yan Chen, Hölscher Christina, Zhazykbayeva Saltanat, Jarkas Oliver, Zou Chendan, Cyganek Lukas, Zorio Esther, Braza-Boils Aitana, Pablo Ochoa Juan, Rehbehn Niels, Fan Xuehui, Lei Xinhao, Liu Rui, Tong Siyuan, Liu Feng, Xue Zongqian, Bober Sara L, Zhao Binyi, Duru Firat, Aweimer Assem, Köppel Alexandra, Burau Karin, Mügge Andreas, Berger Wolfgang, Hamdani Nazha, Zhou Xiaobo, Saguner Ardan M, Akin Ibrahim, Gollob Michael H, El-Battrawy Ibrahim
Abstract excerpt
BACKGROUND AND AIMS: Short QT syndrome (SQTS) is an inherited channelopathy that can cause sudden cardiac death. Recent research has implicated mutations in the SLC4A3 gene as a cause of SQTS, but the mechanisms of shortened action potential duration (APD) and arrhythmia vulnerability have not been described. This study aims to evaluate the underlying pathophysiology causing a shortened APD and ventricular...
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