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Article

Defining Cardiomyocyte Repolarization Response to Pharmacotherapy in Long-QT Syndrome Type 3.

Journal of the American Heart Association - 15 Oct 2024

Ge Ning, Li Rui, Liu Min, Xia Wenxin, O'Brien Stephen T, McInerney Veronica, Galvin Joseph, Ward Deirdre, McGorrian Catherine, O'Brien Timothy, Shen Sanbing, Prendiville Terence W

Abstract excerpt

BACKGROUND: Long-QT syndrome is a primary cardiac ion channelopathy predisposing a patient to ventricular arrhythmia through delayed repolarization on the resting ECG. We aimed to establish a patient-specific, human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes model of long-QT syndrome type 3 (LQT3) using clustered regularly interspaced palindromic repeats (CRISPR/Cas9), for disease modeling and...

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Action Potentials
Anti-Arrhythmia Agents
Calcium Channel Blockers
Cardiac Conduction System Disease
Gene Editing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Long QT Syndrome

Myocytes, Cardiac

NAV1.5 Voltage-Gated Sodium Channel

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Identifiers

PMID: 39377211
DOI: 10.1161/JAHA.124.034690
PMCID: PMC11935574

Genes

SCN5A

Variants

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