Article

Unveiling genetic architecture of white matter microstructure through unsupervised deep representation learning of fractional anisotropy maps

2025-09-17

Abstract excerpt

<title>Abstract</title> <p> Fractional anisotropy (FA) derived from diffusion MRI is a widely used marker of white matter (WM) integrity. However, conventional FA-based genetic studies focus on phenotypes representing tract- or atlas-defined averages, which may oversimplify spatial patterns of WM integrity and thus limit the genetic discovery. Here, we proposed a deep learning–based framework, termed unsupervise...

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Literature Corpus work: f6825057-cf38-51c8-8480-52f7da53d0a2
DOI: 10.21203/rs.3.rs-7411165/v1

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