Article
Integrative multi-omics framework for causal gene discovery in Long COVID.
PLoS computational biology - 1 Dec 2025
Pinero Sindy, Li Xiaomei, Liu Lin, Li Jiuyong, Lee Sang Hong, Winter Marnie, Nguyen Thin, Zhang Junpeng, Le Thuc Duy
Abstract excerpt
Long COVID, or Post-Acute Sequelae of SARS-CoV-2 infection (PASC), affects an estimated 10-20% of COVID-19 patients and presents persistent multisystemic symptoms. Although demographic and clinical factors, such as age, sex, and comorbidities, contribute to risk, the genetic mechanisms underlying this risk remain poorly defined. To address this gap, we developed a multi-omics framework that integrates...
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