Article
Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity.
EBioMedicine - 1 Mar 2021
Fadista João, Kraven Luke M, Karjalainen Juha, Andrews Shea J, Geller Frank, Baillie J Kenneth, Wain Louise V, Jenkins R Gisli, Feenstra Bjarke
Abstract excerpt
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, characterized by progressive lung scarring. Severe COVID-19 is associated with substantial pneumonitis and has a number of shared major risk factors with IPF. This study aimed to determine the genetic correlation between IPF and severe COVID-19 and assess a potential causal role of genetically increased risk of IPF on COVID-19 severity....
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