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Article

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.

Nature communications - 18 Jan 2023

Saarentaus Elmo C, Karjalainen Juha, Rämö Joel T, Kiiskinen Tuomo, Havulinna Aki S, Mehtonen Juha, Hautakangas Heidi, Ruotsalainen Sanni, Tamlander Max, Mars Nina, Toppila-Salmi Sanna, Pirinen Matti, Kurki Mitja, Ripatti Samuli, Daly Mark, Palotie Tuula, Mäkitie Antti, Palotie Aarno

Abstract excerpt

Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the sinonasal tract, pharynx and larynx, are growing health problems yet their genomic similarity is not known. We analyze genome-wide association to eight upper respiratory diseases (61,195 cases) among 260,405 FinnGen participants, meta-analyzing diseases in four groups based on an underlying genetic correlation...

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Identifiers

PMID: 36653354
DOI: 10.1038/s41467-022-33626-w
PMCID: PMC9849224

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