Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site.

doi:10.1016/j.celrep.2026.117664

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site.

Cell reports - 28 Jul 2026

Ko Fu-Hsuan, Lukens Amanda K, Laureano de Souza Mariana, Foy Alex, Hsiao Jason, Ndiaye Tolla, Okombo John, Yeo Tomas, Park Heekuk, Uhlemann Anne-Catrin, Boonyalai Nonlawat, Kumpornsin Krittikorn, Girling Gareth, Pasaje Charisse, Godoy Luiz, Kapoor Priyan, Durst Gregory L, Ottilie Sabine, Chatterjee Arnab, Niles Jacquin, Lee Marcus, Fidock David A, Wirth Dyann F, Winzeler Elizabeth A

Abstract excerpt

Drug resistance poses a major challenge across therapeutic areas including malaria, yet factors governing resistance propensity remain poorly understood. We demonstrate that two HSP90 inhibitors targeting the identical ATP-binding site exhibit dramatically different resistance profiles in P. falciparum. Geldanamycin readily selected 10 distinct resistance mutations conferring up to 22-fold resistance, while...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Benzoquinones

Share to Binding Sites

Share to Drug Resistance

Share to HSP90 Heat-Shock Proteins

Share to Lactams, Macrocyclic

Share to Plasmodium falciparum

Share to Protozoan Proteins

Source

Open in PubMed

Identifiers

PMID: 42406593
DOI: 10.1016/j.celrep.2026.117664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site.PMID 42406593Read ↗

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistanceSemantic proximity Read ↗

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial ResistanceSemantic proximity Read ↗

A broad analysis of resistance development in the malaria parasite.Semantic proximity Read ↗

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.Semantic proximity Read ↗

Mutational 'hot-spots' in mammalian, bacterial and protozoal dihydrofolate reductases associated with antifolate resistance: sequence and structural comparison.Semantic proximity Read ↗

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.Semantic proximity Read ↗

Mechanistic insights into dual-active liver and blood-stage antiplasmodials.Semantic proximity Read ↗

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan.Semantic proximity Read ↗

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.Semantic proximity Read ↗

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised targetSemantic proximity Read ↗

Dual functional genomics reveals a broad and convergent landscape of asciminib resistance in BCR::ABL1.Semantic proximity Read ↗

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.