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Article

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi.

Science (New York, N.Y.) - 30 Sept 2005

Cowen Leah E, Lindquist Susan

Abstract excerpt

Hsp90 is a molecular chaperone for many signal transducers and may influence evolution by releasing previously silent genetic variation in response to environmental change. In fungi separated by approximately 800 million years of evolution, Hsp90 potentiated the evolution of drug resistance in a different way, by enabling new mutations to have immediate phenotypic consequences. Resistance was abrogated by Hsp90...

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PMID: 16195452
DOI: 10.1126/science.1118370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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