Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.

doi:10.1128/AAC.00771-21

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Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates.

Antimicrobial agents and chemotherapy - 17 Sept 2021

Kreutzfeld Oriana, Rasmussen Stephanie A, Ramanathan Aarti A, Tumwebaze Patrick K, Byaruhanga Oswald, Katairo Thomas, Asua Victor, Okitwi Martin, Orena Stephen, Legac Jennifer, Conrad Melissa D, Nsobya Samuel L, Aydemir Ozkan, Bailey Jeffrey, Duffey Maelle, Bayles Brett R, Vaidya Akhil B, Cooper Roland A, Rosenthal Philip J

Abstract excerpt

Among novel compounds under recent investigation as potential new antimalarial drugs are three independently developed inhibitors of the Plasmodium falciparum P-type ATPase (PfATP4): KAE609 (cipargamin), PA92, and SJ733. We assessed ex vivo susceptibilities to these compounds of 374 fresh P. falciparum isolates collected in Tororo and Busia districts, Uganda, from 2016 to 2019. Median IC50s were 65 nM for SJ733,...

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PMID: 34339273
DOI: 10.1128/AAC.00771-21
PMCID: PMC8448140

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