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Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

4 Feb 2013

Abstract excerpt

Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate. Novel strategies to circumvent resistance are needed. Here we detail drug development focusing on heat shock protein 90 and its central role as a chaperone. A growing body of evidence supports...

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PMID: 25436880
DOI: 10.3390/pathogens2010033

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