Lack of association between the Cytochrome P450 4F2 rs2108622 genotype and responses to valsartan and amlodipine among a sample of Jordanian hypertensive patients.

Abstract excerpt

BACKGROUND: The Cytochrome 4F2 (CYP4F2) rs2108622 genetic variant influences the production of 20-Hydroxyeicosatetraenoic acid (20-HETE), which affects the blood pressure. Previous findings from our group indicate that CYP4F2 rs2108622 genotype is associated with essential hypertension. AIMS: This study aims to find out the association of CYP4F2 rs2108622 genotype with the response of valsartan and amlodipine...