Association between CYP11B2 rs1799998 genetic variant with essential hypertension and antihypertensive response.

doi:10.1080/17410541.2025.2607956

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Article

Association between CYP11B2 rs1799998 genetic variant with essential hypertension and antihypertensive response.

Personalized medicine - 1 Dec 2025

Abdelrazaq Dalia, Jarrar Yazun, Alhawari Hussein, Zihlif Malek

Abstract excerpt

BACKGROUND: Essential hypertension (EH) is influenced by genetic and environmental factors. The CYP11B2 gene, encoding aldosterone synthase, plays a major role in blood pressure regulation. This study investigated the association of the CYP11B2 -344C/T (rs1799998) variant with EH in Jordanians and evaluated its influence on response to amlodipine and valsartan. METHODS: A case-control study was conducted...

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Identifiers

PMID: 41451765
DOI: 10.1080/17410541.2025.2607956

Genes

CYP11B2
DBP

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