Article
Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.
International journal of medical sciences - 1 Jan 2021
Al-Eitan Laith N, Almasri Ayah Y, Alnaamneh Adan H, Aman Hatem A, Alrabadi Nasr N, Khasawneh Rame H, Alghamdi Mansour A
Abstract excerpt
Cardiovascular diseases are among the leading causes of death worldwide. Many of those diseases require treatment with warfarin, an anticoagulant that has a large high inter and intra-variability in the required doses. The aim of this study is to find if there are any associations between rs2108622 of CYP4F2, rs7412 and rs405509 of ApoE, and rs1801272 of CYP2A6, and CVD and warfarin dose variability. The selected...
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