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Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease

6 Jun 2020

Abstract excerpt

Neurofilament light chain (NfL) is a protein that is selectively expressed in neurons. Increased levels of NfL measured in either cerebrospinal fluid or blood is thought to be a biomarker of neuronal damage in neurodegenerative diseases. However, there have been limited investigations relating NfL to the concurrent measures of white matter (WM) decline that it should reflect. White matter damage is a common...

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PMID: 32522711
DOI: 10.1016/j.nbd.2020.104960

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