Genomic loss of MLH1/PMS2 loci defines a mismatch repair deficient subgroup in monomorphic epitheliotropic intestinal T-cell lymphoma.

doi:10.1038/s41408-026-01562-3

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Article

Genomic loss of MLH1/PMS2 loci defines a mismatch repair deficient subgroup in monomorphic epitheliotropic intestinal T-cell lymphoma.

Blood cancer journal - 3 Jul 2026

Veloza Luis, Fischer Anja, Rattina Vimel, Vallois David, Sarkis Rita, Lefort Karine, Bisig Bettina, Cavalieri Doriane, Tournilhac Olivier, Gaulard Philippe, Siebert Reiner, de Leval Laurence, Missiaglia Edoardo

Abstract excerpt

Primary intestinal T-cell lymphomas (ITCLs), comprising enteropathy-associated T-cell lymphoma (EATL) and monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), are rare aggressive tumors. The role of DNA mismatch repair (MMR) deficiency (dMMR) and microsatellite instability (MSI) in the development of ITCLs remains largely unexplored. Here, we investigated the incidence, molecular mechanisms and...

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Topics

Humans
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1
Female
DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Microsatellite Instability

Aged

Middle Aged

Enteropathy-Associated T-Cell Lymphoma

Intestinal Neoplasms

DNA Methylation

Mutation

Adult

Aged, 80 and over

Source

Open in PubMed Open full text

Identifiers

PMID: 42399231
DOI: 10.1038/s41408-026-01562-3
PMCID: PMC13601611

Genes

MLH1
PMS2
MSH2
MSH6
SETD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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