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Article

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.

Nature communications - 7 Sept 2016

Roberti Annalisa, Dobay Maria Pamela, Bisig Bettina, Vallois David, Boéchat Cloé, Lanitis Evripidis, Bouchindhomme Brigitte, Parrens Marie-Cécile, Bossard Céline, Quintanilla-Martinez Leticia, Missiaglia Edoardo, Gaulard Philippe, de Leval Laurence

Abstract excerpt

Enteropathy-associated T-cell lymphoma (EATL), a rare and aggressive intestinal malignancy of intraepithelial T lymphocytes, comprises two disease variants (EATL-I and EATL-II) differing in clinical characteristics and pathological features. Here we report findings derived from whole-exome sequencing of 15 EATL-II tumour-normal tissue pairs. The tumour suppressor gene SETD2 encoding a non-redundant H3K36-specific...

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Share to Gene Expression Regulation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histone-Lysine N-Methyltransferase

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Source

Open in PubMed Open full text

Identifiers

PMID: 27600764
DOI: 10.1038/ncomms12602
PMCID: PMC5023950

Genes

SETD2
JAK3
BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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