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Article

Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2018

Din Shahida, Wong Kim, Mueller Mike F, Oniscu Anca, Hewinson James, Black Catherine J, Miller Martin L, Jiménez-Sánchez Alejandro, Rabbie Roy, Rashid Mamunar, Satsangi Jack, Adams David J, Arends Mark J

Abstract excerpt

Purpose: Inflammatory bowel disease-associated colorectal cancers (IBD-CRC) are associated with a higher mortality than sporadic colorectal cancers. The poorly defined molecular pathogenesis of IBD-CRCs limits development of effective prevention, detection, and treatment strategies. We aimed to identify biomarkers using whole-exome sequencing of IBD-CRCs to guide individualized management.Experimental Design:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29950348
DOI: 10.1158/1078-0432.CCR-17-3713
PMCID: PMC6193541

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MLH1
POLE

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