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Article

Microsatellite Instability as a Biomarker for PD-1 Blockade

14 Feb 2016

Abstract excerpt

Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the New England Journal of Medicine, report significant responses of cancers with microsatellite instability (MSI) to anti-PD-1 inhibitors in patients who failed conventional therapy. This finding fits into a broader body of research associating somatic hypermutation and neoepitope formation with response to immunotherapy,...

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PMID: 26880610
DOI: 10.1158/1078-0432.ccr-15-1678

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