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Article

Lynch-like syndrome: characterization and comparison with EPCAM deletion carriers.

International journal of cancer - 1 Apr 2015

Kang So Young, Park Cheol Keun, Chang Dong Kyung, Kim Jong Won, Son Hee Jung, Cho Yong Beom, Yun Seong Hyeon, Kim Hee Cheol, Kwon Moosik, Kim Kyoung-Mee

Abstract excerpt

Colorectal cancers (CRCs) with microsatellite instability-high (MSI+) but without detectable germline mutation or hypermethylation in DNA mismatch repair (MMR) genes can be classified as Lynch-like syndrome (LLS). The underlying mechanism and clinical significances of LLS are largely unknown. We measured MSI and MMR protein expression in 4,765 consecutive CRC cases. Among these, MSI+ cases were further classified...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to DNA Mismatch Repair

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Source

Identifiers

PMID: 25110875
DOI: 10.1002/ijc.29133

Genes

EPCAM
POLE
MSH2
MLH1
POLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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