Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.

doi:10.1161/ATVBAHA.126.324325

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Article

Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2026

Grobs Yann, Lemay Sarah-Eve, Mougin Manon, Thberge Charlie, Boucher Magalie, Breuils-Bonnet Sandra, Martineau Sandra, Bourgeois Alice, Pelletier Andreanne, Fillon Maud, Perron Jean, Potus François, Provencher Steeve, Boucherat Olivier, Bonnet Sebastien

Abstract excerpt

BACKGROUND: Post-surgical restenosis in patients with coronary artery disease (CAD) is a pathological vascular remodeling process characterized by neointimal hyperplasia, which is mainly driven by phenotypic switching of vascular smooth muscle cells toward a synthetic and proliferative state. This study investigated a novel signaling pathway to promote the proproliferative phenotype of vascular smooth muscle...

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