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Article

The ADP antagonist MRS2179 regulates the phenotype of smooth muscle cells to limit intimal hyperplasia.

Cardiovascular drugs and therapy - 1 Feb 2015

Liu Rong, Ma Shixin, Lu Zhigang, Shen Hong, Sun Leiqing, Wei Meng

Abstract excerpt

PURPOSE: ADP plays an important part in platelet aggregation by activating P2Y1 and P2Y12 receptors. The ADP antagonist MRS2179 has been used in thrombosis-related treatments but its effects on vein graft (VG) remodeling is undefined. We examined the effect of MRS2179 on VG intimal hyperplasia and explored the mechanism of action. METHODS: A mouse model of VG transplantation was established. Mice underwent...

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Share to Adenosine Diphosphate
Share to Hyperplasia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinases

Share to Myocytes, Smooth Muscle

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Share to Proto-Oncogene Proteins c-akt

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PMID: 25528944
DOI: 10.1007/s10557-014-6561-6

Genes

TNF

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