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Article

PDCD1 gene polymorphisms linked with altered risk of female-specific hormone-dependent cancers: a systematic review and meta-analysis.

BMC cancer - 1 Jul 2026

Zidi Sabrina, BenAbdelmoumenMardassi Boutheina, Sahraoui Ghada, Almawi Wassim Y

Abstract excerpt

BACKGROUND: The programmed cell death-1 (PDCD1) gene plays a critical role in immune regulation and tumor immune evasion, making it a key target in cancer immunotherapy. Genetic variants in PDCD1, including rs2227981, rs2227982, rs7421861, and rs11568821, may influence susceptibility to female-specific cancers. This systematic review and meta-analysis aimed to evaluate the association of these variants with the...

Read the complete abstract on PubMed

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Topics

Humans
Female
Programmed Cell Death 1 Receptor
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Neoplasms, Hormone-Dependent
Ovarian Neoplasms
Case-Control Studies
Odds Ratio

Source

Open in PubMed Open full text

Identifiers

PMID: 42387483
DOI: 10.1186/s12885-026-16394-4
PMCID: PMC13591861

Genes

PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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