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PD-1 polymorphisms are associated with sporadic breast cancer in Chinese Han population of Northeast China.

Breast cancer research and treatment - 1 Aug 2011

Hua Zhang, Li Dalin, Xiang Gao, Xu Fengyan, Jie Guan, Fu Zhenkun, Jie Zhang, Da Pang, Li Dianjun

Abstract excerpt

The programmed death-1 (PD-1) is a potent immunoregulatory molecule which is responsible for the negative regulation of T-cell activation and peripheral tolerance. In order to investigate the association between polymorphisms of PD-1 and breast cancer, a case-control study was conducted in Chinese female population consisting of 490 cases with breast cancer and 512 age-matched healthy individuals from...

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PMID: 21487727
DOI: 10.1007/s10549-011-1440-3

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