Article
Program death 1 (PD1) haplotyping in patients with breast carcinoma.
Molecular biology reports - 1 Aug 2011
Haghshenas Mohammad Reza, Naeimi Sirous, Talei Abdolrasoul, Ghaderi Abbas, Erfani Nasrollah
Abstract excerpt
Located on chromosome 2q37.3, the programmed death 1 (PD1) gene encodes for PD-1 (also known as CD279), a negative co-stimulator in the immune system. PD-1 renders potent inhibitory effects on T and B lymphocytes as well as monocyte responses. Expression of PD-1 ligands by tumor cells has been reported to contribute in immune system evasion. We aimed, in current study, to investigate the association of two single...
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