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Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies.

Aging - 27 Mar 2024

Yang Maoquan, Liu Yan, Zheng Shuangshuang, Geng Peizhen, He Tianhao, Lu Linan, Feng Yikuan, Jiang Qiqi

Abstract excerpt

Programmed death-1 and its ligand-1 (PD-1/PD-L1), immune checkpoints proteins, play a crucial role in anti-tumor responses. A large number of studies have evaluated the relationships of PD-1/PD-L1 polymorphisms with risk of cancer, but evidence for the associations remains inconsistent. Therefore, we performed a meta-analysis to examine the associations between PD-1/PD-L1 single nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 38546391
DOI: 10.18632/aging.205689
PMCID: PMC11042937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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