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Article

Sex modifies the effect of genetic risk scores for polycystic ovary syndrome on metabolic phenotypes.

PLoS genetics - 1 May 2023

Actkins Ky'Era V, Jean-Pierre Genevieve, Aldrich Melinda C, Velez Edwards Digna R, Davis Lea K

Abstract excerpt

Females with polycystic ovary syndrome (PCOS), the most common endocrine disorder in women, have an increased risk of developing cardiometabolic disorders such as insulin resistance, obesity, and type 2 diabetes (T2D). While only diagnosable in females, males with a family history of PCOS can also exhibit a poor cardiometabolic profile. Therefore, we aimed to elucidate the role of sex in the cardiometabolic...

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Identifiers

PMID: 37256887
DOI: 10.1371/journal.pgen.1010764
PMCID: PMC10259776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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