Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

doi:10.1136/gutjnl-2016-312423

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Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.

Gut - 1 Mar 2017

Hohwieler Meike, Illing Anett, Hermann Patrick C, Mayer Tobias, Stockmann Marianne, Perkhofer Lukas, Eiseler Tim, Antony Justin S, Müller Martin, Renz Susanne, Kuo Chao-Chung, Lin Qiong, Sendler Matthias, Breunig Markus, Kleiderman Susanne M, Lechel André, Zenker Martin, Leichsenring Michael, Rosendahl Jonas, Zenke Martin, Sainz Bruno, Mayerle Julia, Costa Ivan G, Seufferlein Thomas, Kormann Michael, Wagner Martin, Liebau Stefan, Kleger Alexander

Abstract excerpt

OBJECTIVE: The generation of acinar and ductal cells from human pluripotent stem cells (PSCs) is a poorly studied process, although various diseases arise from this compartment. DESIGN: We designed a straightforward approach to direct human PSCs towards pancreatic organoids resembling acinar and ductal progeny. RESULTS: Extensive phenotyping of the organoids not only shows the appropriate marker profile but also...

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PMID: 27633923
DOI: 10.1136/gutjnl-2016-312423
PMCID: PMC5534761

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