Current clinical opinion on CFTR dysfunction and patient risk of pancreatitis: diagnostic and therapeutic considerations.

doi:10.1080/17474124.2022.2084072

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Article

Current clinical opinion on CFTR dysfunction and patient risk of pancreatitis: diagnostic and therapeutic considerations.

Expert review of gastroenterology & hepatology - 1 Jun 2022

Phadke Madhura Y, Sellers Zachary M

Abstract excerpt

INTRODUCTION: Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated chloride and bicarbonate secretion is integral to the pancreas' ability to produce the alkaline pancreatic juice required for proper activation of enzymes for digestion. Disruption in this process increases the risk for pancreatitis. AREAS COVERED: Using original basic and clinical research, as well as clinical case reports and...

Topics

Chlorides
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Exocrine Pancreatic Insufficiency
Humans
Mutation
Pancreatitis

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Identifiers

PMID: 35623009
DOI: 10.1080/17474124.2022.2084072
PMCID: PMC9256802

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