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Article

HPV16 is sufficient to induce squamous cell carcinoma specifically in the tongue base in transgenic mice

29 Jan 2020

Abstract excerpt

Abstract Head and neck squamous cell carcinomas (HNSCCs) associated with human papillomavirus (HPV) occur specifically in the tonsils and the tongue base, but the reasons for this specificity remain unknown. We studied the distribution of oral and pharyngeal lesions in HPV16‐transgenic mice where the expression of all the HPV16 early genes is targeted to keratinising squamous epithelia by the cytokeratin 14...

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PMID: 31994197
DOI: 10.1002/path.5387

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