Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.

doi:10.1093/carcin/bgaa027

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Article

Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.

Carcinogenesis - 13 Nov 2020

Böttinger Paula, Schreiber Karin, Hyjek Elizabeth, Krausz Thomas, Spiotto Michael T, Steiner Madeline, Idel Christian, Booras Heather, Beck-Engeser Gabriele, Riederer Jessie, Willimsky Gerald, Wolf Steven P, Karrison Theodore, Jensen Elizabeth, Weichselbaum Ralph R, Nakamura Yusuke, Yew Poh Yin, Lambert Paul F, Kurita Takeshi, Kiyotani Kazuma, Leisegang Matthias, Schreiber Hans

Abstract excerpt

Human papillomavirus (HPV) infection is necessary but insufficient for progression of epithelial cells from dysplasia to carcinoma-in situ (CIS) to invasive cancer. The combination of mutant cellular and viral oncogenes that regulate progression of cervical cancer (CC) remains unclear. Using combinations of HPV16 E6/E7 (E+), mutant Kras (mKras) (K+) and/or loss of Pten (P-/-), we generated autochthonous models of...

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PMID: 32221533
DOI: 10.1093/carcin/bgaa027
PMCID: PMC7896110

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Source receipt: pubmed, retrieved 7 Sept 2026.

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