Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury

8 Jun 2016

Abstract excerpt

A validated animal model would assist with research on the immunological consequences of the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human pre-malignant hyperproliferative epithelium. Here we examine keratin gene expression profile in skin from mice expressing the E7 oncoprotein of HPV16 (K14E7) demonstrating persistently hyperproliferative epithelium, in nontransgenic mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Skin and Cellular Biology Research
Share to Skin Protection and Aging
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27333029
DOI: 10.1016/j.ebiom.2016.06.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to InjuryPMID 27333029Read ↗

Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic miceSemantic proximity Read ↗

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogeneSemantic proximity Read ↗

MmuPV1 E7 promotes phenotypes associated with "high-risk" HPV infection in mouse keratinocytes.Semantic proximity Read ↗

Tissue Context Shapes Distinct Premalignant Outcomes in an HPV16 E6/E7-Mutant Pik3ca Transgenic Mouse Model.Semantic proximity Read ↗

Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice.Semantic proximity Read ↗

Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin.Semantic proximity Read ↗

Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.Semantic proximity Read ↗

HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transitionSemantic proximity Read ↗

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals.Semantic proximity Read ↗

Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice.Semantic proximity Read ↗

Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.Semantic proximity Read ↗

Increased Levels of Keratin 16 Alter Epithelialization Potential of Mouse Skin Keratinocytes In Vivo and Ex VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.