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Article

Genomic Stratification of Resectable Colorectal Liver Metastasis Patients and Implications for Adjuvant Therapy and Survival.

Annals of surgery - 1 Feb 2022

Ecker Brett L, Shin Paul, Saadat Lily V, Court Colin M, Balachandran Vinod P, Chandwani Rohit, Drebin Jeffrey A, Jarnagin William R, Kingham T Peter, Soares Kevin C, Vakiani Efsevia, Wei Alice C, Kemeny Nancy E, Smith J Joshua, Gonen Mithat, D'Angelica Michael I

Abstract excerpt

OBJECTIVE: To determine whether genomic risk groups identified by somatic mutation testing of colorectal liver metastasis (CRLM) can be used for "molecularly-guided" selection for adjuvant systemic chemotherapy and hepatic artery infusion of FUDR (SYS+HAI-FUDR). BACKGROUND: Several genomic biomarkers have been associated with clinical phenotype and survival for patients with resectable CRLM. It is unknown whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34793355
DOI: 10.1097/SLA.0000000000005315
PMCID: PMC8754193

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