Article
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups.
Frontiers in immunology - 1 Jan 2023
Hurler Lisa, Szilágyi Ágnes, Mescia Federica, Bergamaschi Laura, Mező Blanka, Sinkovits György, Réti Marienn, Müller Veronika, Iványi Zsolt, Gál János, Gopcsa László, Reményi Péter, Szathmáry Beáta, Lakatos Botond, Szlávik János, Bobek Ilona, Prohászka Zita Z, Förhécz Zsolt, Csuka Dorottya, Kajdácsi Erika, Cervenak László, Kiszel Petra, Masszi Tamás, Vályi-Nagy István, Würzner Reinhard, Lyons Paul A, Toonen Erik J M, Prohászka Zoltán
Abstract excerpt
Introduction: While complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin...
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