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Article

Genomic Evidence on Antihypertensive Drug Targets and Oral Disease Outcomes.

Journal of periodontal research - 1 Jun 2026

Puzhakkara Chennas Aiswarya, Leiva-Escobar Ignacio, Reckelkamm Stefan Lars, Holtfreter Birte, Kocher Thomas, Baumeister Sebastian-Edgar, Nolde Michael, Alayash Zoheir

Abstract excerpt

AIM: Antihypertensive medications are widely prescribed for hypertension, yet evidence regarding their oral health safety remains limited. We aimed to investigate whether genetically proxied pharmacological actions of antihypertensive drug classes influence the risk of periodontitis and dental caries using a two-sample drug-target Mendelian randomization framework. METHODS: Genetic instruments were obtained for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 42366644
DOI: 10.1111/jre.70143
PMCID: PMC13471875

Genes

KCNJ11
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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