Article

Using human genetics to validate complement C3 as a drug target in periodontitis

2023-02-21

Abstract excerpt

<h4>Aim</h4> Evidence from a phase IIa trial showed that a complement C3-targeted drug reduced gingival inflammation in patients with gingivitis. We investigated the therapeutic effect of genetically proxied C3 inhibition on periodontitis using drug target Mendelian randomization (MR). <h4>Materials and methods</h4> We used multiple ‘cis’ instruments from the vicinity of the encoding loci of C3 that are associated...

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Literature Corpus work: e8a5ce61-d0a3-585e-b230-8b18a44532ef
DOI: 10.1101/2023.02.13.23285838

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