Article

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers

2021-03-12

Abstract excerpt

<h4>Background</h4> Epidemiological studies have reported conflicting findings on the potential adverse effects of long-term antihypertensive medication use on cancer risk. Naturally occurring variation in genes encoding antihypertensive drug targets can be used as proxies for these targets to examine the effect of their long-term therapeutic inhibition on disease outcomes. <h4>Methods</h4> Single-nucleotide polym...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cbf79be-166e-5d7d-8284-2fa02b333aa2
DOI: 10.1101/2021.03.11.21252971

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetically-proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancersDOI 10.1101/2021.03.11.21252971Read

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.Semantic proximity Read

Association between antihypertensive drugs and hepatocellular carcinoma: A trans-ancestry and drug-target Mendelian randomization study.Semantic proximity Read

Genetically-proxied anti-diabetic drug target perturbation and risk of cancer: a Mendelian randomization analysisSemantic proximity Read

Antihypertensive drug targets and breast cancer risk: a two-sample Mendelian randomization study.Semantic proximity Read

Genetically proxied inhibition of angiotensinogen synthesis is associated with lower cardiovascular riskSemantic proximity Read

Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis.Semantic proximity Read

Identification of Novel Therapeutic Targets for Hypertension.Semantic proximity Read

Effect of genetically proxied use of PDE5 inhibitors on risk of CHD: A drug target Mendelian Randomization studySemantic proximity Read

The evolution of mendelian randomization for investigating drug effects.Semantic proximity Read

Using genetics to assess the association of commonly used antihypertensive drugs with diabetes, glycaemic traits and lipids: a trans-ancestry Mendelian randomisation studySemantic proximity Read

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side EffectsSemantic proximity Read

Triangulating Evidence for Antihypertensive Drug Class Efficacy on Cardiovascular and Metabolic Outcomes Using Mendelian Randomisation and ColocalisationSemantic proximity Read