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Article

Large-scale imaging genetics reveals causal effects of brain microstructure across the epilepsy spectrum.

Neurobiology of disease - 1 Jul 2026

Peng Lequn, Shi Yiming, Zhao Tao, Zhu Hongjie, Chen Biyi, Zhang Wei, Ding Huang

Abstract excerpt

BACKGROUND: The causal relationship between brain structures and epilepsy remains unclear. This study integrates genomic and neuroimaging data to bridge the gap between epilepsy genetics and brain imaging, supporting advances in precision medicine. METHODS: We employed a comprehensive pipeline-including Mendelian randomization (MR), linkage disequilibrium score regression (LDSC), co-localization, and multi-gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42134559
DOI: 10.1016/j.nbd.2026.107442

Genes

HAS3
CALCRL
CPED1
MAPT
RAPGEF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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