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Article

Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte-mediated etiology of epileptic cortical thinning.

Epilepsia open - 1 Jun 2026

Zhang Dingyuan, Zhang Qianqian, Li Guangming, Yu Lingting, Ma Yanling, Hong Xiaoli, Kui Yujie, Cai Shanshan, Sun Jianguang, Zhu Zechao

Abstract excerpt

OBJECTIVE: Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure-induced damage or shared genetic predisposition remains unresolved. METHODS: We integrated genome-wide association study (GWAS) summary statistics from the ILAE Consortium (focal epilepsy: 15212 cases; 29 677 controls), ENIGMA (cortical...

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Source

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Identifiers

PMID: 41885647
DOI: 10.1002/epi4.70251
PMCID: PMC13238687

Genes

DPYSL5
SLC16A8
CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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