Unveiling causal relationships between inflammatory cytokines and neurite orientation dispersion and density imaging phenotypes: Insights from bidirectional Mendelian randomization and bibliometric analysis.

Abstract excerpt

BACKGROUND: Inflammatory factors interact with brain imaging-derived phenotypes (IDPs); however, the specific causal relationships between inflammatory factors and brain white matter (WM)-related IDPs remain unclear. Thus, we sought to analyze the potential causal effects of inflammatory factors on brain WM-related IDPs using Mendelian randomization (MR). METHODS: We obtained the data of 41 inflammatory factors...

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• Cytokines
• Genome-Wide Association Study
• Inflammation
• Mendelian Randomization Analysis
• Neurites