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Article

A Greek Case-Control Replication Study of IKZF1 rs4132601 and CDKN2A rs3731217 in Childhood Acute Lymphoblastic Leukemia.

Genes - 10 Jun 2026

Kyriakidis Ioannis, Katsarou Spyridoula D, Zervou Maria I, Katzilakis Nikolaos, Stratigaki Maria, Pelagiadis Iordanis, Stiakaki Eftichia

Abstract excerpt

BACKGROUND/OBJECTIVES: Inherited variants in IKZF1 and CDKN2A/2B are among the most consistently reported germline susceptibility markers for childhood acute lymphoblastic leukemia (ALL). Nonetheless, effect sizes differ across ancestry groups, age ranges, and immunophenotypic subtypes, making well-characterized population-specific replication studies valuable for refining ancestry-specific evidence. This study...

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Source

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Identifiers

PMID: 42353840
DOI: 10.3390/genes17060682
PMCID: PMC13300321

Genes

CDKN2A
IKZF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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