Article
Polymorphism in IKZF1 gene affects age at onset of childhood acute lymphoblastic leukemia.
Leukemia & lymphoma - 1 Sept 2014
Górniak Patryk, Pastorczak Agata, Zalewska-Szewczyk Beata, Lejman Monika, Trelińska Joanna, Chmielewska Marta, Sokół-Jeżewska Agnieszka, Kowalczyk Jerzy, Szczepanski Tomasz, Matysiak Michał, Kazanowska Bernarda, Mlynarski Wojciech
Abstract excerpt
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, characterized by a peak of incidence between 2 and 5 years. Since recently conducted genome-wide association (GWA) studies revealed that the common low-penetrance susceptibility allele at 7p12.2 (IKZF1 gene) confers an increased risk of pediatric ALL, we investigated whether the risk allele at rs4132601 also coexists with well-established...
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